Understanding how Coxiella burnetii causes Q-fever
Official title: The Role of Coxiella Effector Proteins in Infection and Disease
Funded at Yale University · NIH-11133660 · Data updated 2026-11-12
This study is looking at how the bacteria that cause Q-fever trick our body's cells to survive and multiply, which could help us find better ways to prevent and treat this illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 8, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $625,276 |
| NIH project number | 1R56AI182383-01 |
| Project ID | NIH-11133660 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with Q-fever or are at risk of infection from Coxiella burnetii.
✕Less likely to help
Patients who do not have Q-fever or are not at risk of exposure to Coxiella burnetii may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the bacterium Coxiella burnetii manipulates host cells to cause Q-fever. The team will use advanced genetic tools and molecular techniques to identify specific proteins that help the bacteria evade the host's immune system and replicate within cells. By studying how these proteins interact with host cell processes, the research aims to uncover new insights into the infection process and the immune response. This knowledge could lead to improved strategies for preventing and treating infections caused by this pathogen.
Why it matters
Potential benefit: If successful, this research could lead to better treatments and preventive measures for Q-fever and similar infections.
How similar studies have gone: Previous research has shown success in understanding bacterial pathogenesis using similar genetic and molecular approaches, indicating a promising avenue for this investigation.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Roy, Craig R. — Yale University
- Study coordinator: Roy, Craig R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.