Understanding how COVID-19 vaccines work in children with immune deficiencies
SARS-CoV-2 Vaccine Responses in children with genetic or acquired B cell deficiencies
This study is looking at how well COVID-19 vaccines work for kids with certain immune system challenges, to help find the best ways to keep them safe from the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11085985 on NIH RePORTER |
What this research studies
This research investigates the immune responses to COVID-19 vaccines in children who have genetic or acquired B cell deficiencies. It focuses on how these children's developing immune systems respond to the vaccines, particularly in terms of antibody production and overall vaccine efficacy. By examining the differences in immune responses based on age and health status, the study aims to determine the best ways to protect vulnerable pediatric populations from COVID-19. The research will involve analyzing blood samples to measure immune responses and assess the effectiveness of the vaccines.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-20 years who have genetic or acquired B cell deficiencies.
Not a fit: Patients without any immune deficiencies or those over 20 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies for children with immune deficiencies, enhancing their protection against COVID-19.
How similar studies have performed: Previous research has shown that understanding immune responses in pediatric populations can lead to better vaccine outcomes, making this approach promising.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Hsieh, Wen-Yuan E — University of Colorado Denver
- Study coordinator: Hsieh, Wen-Yuan E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.