Understanding how COVID-19 affects the brain and nervous system after infection
Investigating Mechanisms of Neurological Post Acute Sequelae of SARS CoV2 Using Quantitative Multiparametric In-Vivo and Ex-Vivo MRI
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11022042
This study is looking at how COVID-19 might affect the brain in people who have recovered from the virus, especially those experiencing issues like memory problems, tiredness, and mood changes, to help find better ways to treat these symptoms.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11022042 on ClinicalTrials.gov |
What this research studies
This research investigates the long-term neurological effects experienced by individuals who have recovered from COVID-19, known as Post-Acute Sequelae of COVID-19 (PASC). It focuses on understanding the mechanisms by which the virus may cause damage to the brain and brainstem, leading to symptoms such as cognitive impairment, fatigue, and mood disorders. Using advanced MRI techniques, the study aims to identify specific brain changes associated with these neurological symptoms, which could help inform future treatments. By analyzing both in vivo and ex vivo MRI data, the research seeks to uncover the relationship between viral infection, immune response, and neurological damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recovered from COVID-19 but continue to experience neurological symptoms.
Not a fit: Patients who have not been infected with COVID-19 or those without neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from neurological symptoms following COVID-19.
How similar studies have performed: Other research has shown promising results in understanding the neurological impacts of viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEIFERT, ALAN C — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: SEIFERT, ALAN C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute phase of SARS-CoV-2 infection, acute SARS-CoV-2 infection, adverse sequelae of coronavirus disease, adverse sequelae of coronavirus disease 2019