Understanding how COVID-19 affects multiple organs in the body
Metabolic and epigenetic reprogramming of vital organs in SARS-CoV-2 induced systemic toxicity
This study is looking at how COVID-19 affects important organs in the body, not just the lungs, by using mice to see how the virus changes metabolism and immune responses, which could help us understand why some people get really sick from the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10272660 on NIH RePORTER |
What this research studies
This research investigates the effects of SARS-CoV-2 on vital organs beyond the respiratory system, focusing on how the virus causes systemic toxicity. Using a mouse model, the study examines metabolic and epigenetic changes in various organs following infection. Researchers will analyze the immune response and its impact on organ function, including weight loss and heart damage, to better understand the complications associated with COVID-19. The goal is to uncover the underlying mechanisms that lead to severe outcomes in infected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced severe COVID-19 symptoms or complications affecting multiple organ systems.
Not a fit: Patients who have not been infected with SARS-CoV-2 or those with mild cases of COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for COVID-19 patients experiencing multi-organ complications.
How similar studies have performed: Other research has shown that understanding the systemic effects of viral infections can lead to significant advancements in treatment, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Deb, Arjun — University of California Los Angeles
- Study coordinator: Deb, Arjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.