Understanding how COVID-19 affects mitochondrial function and causes oxidative stress in older adults
Characterization the disruption of mitochondrial function and induction of oxidative stress by SARS-CoV2
This study is looking at how the COVID-19 virus affects energy production in the cells of older adults, who may experience more severe symptoms, to help find ways to improve their health and reduce issues like fatigue and shortness of breath.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10640165 on NIH RePORTER |
What this research studies
This research investigates the impact of SARS-CoV-2 on mitochondrial function, particularly in older adults who are at higher risk for severe COVID-19 symptoms. It focuses on how the virus may disrupt energy metabolism and increase oxidative stress, leading to common symptoms like fatigue and shortness of breath. The study employs advanced proteomics and unique cell models to explore the interactions between viral proteins and mitochondrial pathways. By understanding these mechanisms, the research aims to uncover potential therapeutic targets for improving outcomes in affected populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those with compromised mitochondrial function or metabolic syndromes.
Not a fit: Patients who are younger and do not have any underlying metabolic conditions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve energy metabolism and reduce oxidative stress in older adults suffering from COVID-19.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial dysfunction in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Bai, Yidong — University of Texas Hlth Science Center
- Study coordinator: Bai, Yidong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.