Understanding how COVID-19 affects kidney health
Mechanisms of Kidney Injury in COVID-19
This study is looking at how COVID-19 can harm the kidneys, especially in people with a rare kidney problem, to find out if the damage is caused by the virus itself or the body's reaction to it, and it hopes to help improve treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10700050 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind kidney injury in patients with COVID-19, particularly focusing on a rare condition known as collapsing glomerulopathy. The team will analyze kidney tissue samples from affected individuals to determine whether the damage is caused directly by the virus or through indirect effects related to the body's immune response. By utilizing advanced techniques such as genomic analysis and human kidney organoid systems, the study aims to uncover critical insights that could inform treatment strategies for those impacted by COVID-19-related kidney issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced kidney complications due to COVID-19, particularly those with high-risk APOL1 genotypes.
Not a fit: Patients without COVID-19 or those who do not have kidney-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for kidney injuries associated with COVID-19.
How similar studies have performed: Other research has shown promising results in understanding kidney injuries related to viral infections, but this specific investigation into COVID-19 is relatively novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Akilesh, Shreeram — University of Washington
- Study coordinator: Akilesh, Shreeram
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.