Understanding how COVID-19 affects different tissues in the body
Spatial-Temporal Dissection of Stratified Host Tissue Responses to Severe acute respiratory syndrome-related coronaviruses in situ to Understand Intra-host Pathogenesis
This study is looking at how the COVID-19 virus affects our bodies by examining samples from people who have passed away and using special imaging techniques, with the goal of finding better treatments and vaccines that work against different versions of the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10899504 on NIH RePORTER |
What this research studies
This research investigates the interactions between SARS-CoV-2 and host tissues to understand how the virus causes disease. By examining human autopsy samples and using advanced imaging techniques, the study aims to uncover how different variants of the virus affect immune responses and tissue-specific damage. The approach combines genetic tools and animal models to analyze the virus's behavior and the host's response in real-time. This could lead to better antiviral treatments and vaccines tailored to combat COVID-19 variants.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced severe COVID-19 symptoms or have been hospitalized due to the virus.
Not a fit: Patients who have not been infected with COVID-19 or those with mild cases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and vaccines for COVID-19, improving patient outcomes.
How similar studies have performed: Other research has shown promise in understanding viral-host interactions, but this specific approach is novel and aims to provide deeper insights into COVID-19 pathogenesis.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Jiang, Sizun — Beth Israel Deaconess Medical Center
- Study coordinator: Jiang, Sizun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.