Understanding how COUP-TFII affects the development of human veins
Official title: Investigating COUP-TFII in human vein development
Funded at Stanford University · NIH-11066298 · Data updated 2026-11-12
This study is looking at a protein called COUP-TFII to learn more about how veins develop in our bodies, which could help us understand and treat problems like abnormal blood vessel growth and certain cancers.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | January 13, 2025 |
| Project end | January 12, 2028 |
| Funding year | 2025 |
| Award (this year) | $42,507 |
| NIH project number | 1F31HL178013-01 |
| Project ID | NIH-11066298 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with vascular disorders, particularly those related to vein malformations or dysfunction.
✕Less likely to help
Patients with conditions unrelated to vein development or those who do not have vascular disorders may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, COUP-TFII, in the development of veins in humans. By utilizing advanced stem cell differentiation techniques, the study aims to create human vein endothelial cells in the lab to better understand how these cells specialize and function. The research focuses on the mechanisms that may lead to various vascular disorders, including arteriovenous malformations and cancers. Patients may benefit from insights gained into how vein development can be disrupted and how to potentially address these issues.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for vascular disorders related to vein development.
How similar studies have gone: Previous studies using similar approaches in animal models have shown promise, but this research aims to explore these mechanisms specifically in human cells, making it a novel endeavor.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Pyke, Alanna — Stanford University
- Study coordinator: Pyke, Alanna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.