Understanding how coronaviruses change host cell membranes
Investigating the molecular mechanisms of membrane remodeling by coronaviruses
['FUNDING_OTHER'] · DARTMOUTH COLLEGE · NIH-10908717
This study is looking at how coronaviruses, like the one that causes COVID-19, change the cells they infect, with the goal of finding new ways to create better treatments for you and others affected by these viruses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-10908717 on ClinicalTrials.gov |
What this research studies
This research investigates the ways in which coronaviruses, such as SARS-CoV-2, alter the membranes of host cells during infection. By examining the molecular mechanisms involved, particularly the role of specific viral proteins, the research aims to identify potential new targets for antiviral drug development. The approach includes advanced techniques like cryo-electron microscopy to visualize these changes at a cellular level. This understanding could lead to the creation of more effective treatments for COVID-19 and other coronavirus-related illnesses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been infected with coronaviruses or are at high risk for severe respiratory infections caused by these viruses.
Not a fit: Patients who are not affected by coronaviruses or do not have respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral drugs that effectively target coronavirus infections.
How similar studies have performed: Other research has shown promise in targeting viral replication mechanisms, suggesting that this approach could yield significant advancements in antiviral therapies.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAGUSA, MICHAEL JOSEPH — DARTMOUTH COLLEGE
- Study coordinator: RAGUSA, MICHAEL JOSEPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections