Understanding how coronaviruses change host cell membranes
Official title: Investigating the molecular mechanisms of membrane remodeling by coronaviruses
Funded at Dartmouth College · NIH-10908717 · Data updated 2026-11-12
This study is looking at how coronaviruses, like the one that causes COVID-19, change the cells they infect, with the goal of finding new ways to create better treatments for you and others affected by these viruses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | August 16, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $246,000 |
| NIH project number | 5UH2AI178082-02 |
| Project ID | NIH-10908717 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been infected with coronaviruses or are at high risk for severe respiratory infections caused by these viruses.
✕Less likely to help
Patients who are not affected by coronaviruses or do not have respiratory conditions may not benefit from this research.
What this research studies
This research investigates the ways in which coronaviruses, such as SARS-CoV-2, alter the membranes of host cells during infection. By examining the molecular mechanisms involved, particularly the role of specific viral proteins, the research aims to identify potential new targets for antiviral drug development. The approach includes advanced techniques like cryo-electron microscopy to visualize these changes at a cellular level. This understanding could lead to the creation of more effective treatments for COVID-19 and other coronavirus-related illnesses.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral drugs that effectively target coronavirus infections.
How similar studies have gone: Other research has shown promise in targeting viral replication mechanisms, suggesting that this approach could yield significant advancements in antiviral therapies.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Ragusa, Michael Joseph — Dartmouth College
- Study coordinator: Ragusa, Michael Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.