Understanding how corneal cells maintain fluid balance and transparency
Modeling and testing functional interactions among corneal endothelial acid-base transporters
['FUNDING_R21'] · STATE UNIVERSITY OF NEW YORK AT BUFFALO · NIH-11075886
This study is looking at how certain proteins in the eye's cornea work together to keep it healthy and clear, and it aims to find out how changes in these proteins might cause corneal dystrophy, which could help in developing new treatments for this condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY OF NEW YORK AT BUFFALO (nih funded) |
| Locations | 1 site (AMHERST, UNITED STATES) |
| Trial ID | NIH-11075886 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between specific proteins in corneal endothelial cells that are crucial for maintaining corneal hydration and transparency. By using a combination of experimental data and computational modeling, the study aims to understand how mutations in these proteins can lead to corneal dystrophy. The researchers will analyze how these proteins work together to counteract pH changes and maintain proper function. This approach could reveal important insights into the mechanisms behind corneal diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with corneal dystrophies or those experiencing corneal edema.
Not a fit: Patients with corneal conditions unrelated to the function of the studied transport proteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for corneal dystrophies, potentially improving vision and quality of life for affected patients.
How similar studies have performed: While the specific approach of using computational modeling in this context may be novel, similar studies have successfully identified interactions among cellular transporters in other conditions.
Where this research is happening
AMHERST, UNITED STATES
- STATE UNIVERSITY OF NEW YORK AT BUFFALO — AMHERST, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARKER, MARK — STATE UNIVERSITY OF NEW YORK AT BUFFALO
- Study coordinator: PARKER, MARK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.