Understanding how corneal cells communicate during healing and scarring
Mechanisms of corneal stromal activation during regeneration and fibrosis by exosomes
['FUNDING_CAREER'] · SCHEPENS EYE RESEARCH INSTITUTE · NIH-10914877
This study is looking at tiny particles released by cells in the eye to see how they help the cornea heal and whether they can prevent scarring, which could lead to better vision for people with corneal issues.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCHEPENS EYE RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10914877 on ClinicalTrials.gov |
What this research studies
This research investigates the role of extracellular vesicles (EVs) in the healing process of the cornea, particularly focusing on how these vesicles influence cell communication and the formation of scar tissue. By analyzing the secretome of corneal epithelial cells, the study aims to identify the bioactive components that contribute to either healing or fibrosis. The researchers will explore how different factors, such as TGF-β1 and TGF-β3, affect the behavior of corneal fibroblasts and their differentiation into myofibroblasts, which are crucial in scar formation. This work could lead to new therapeutic strategies for preventing corneal scarring and improving visual outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with moderate to severe corneal wounds or scarring that may lead to visual impairment.
Not a fit: Patients with corneal conditions unrelated to scarring or those who do not have significant visual impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce corneal scarring, potentially improving vision for affected patients.
How similar studies have performed: Previous research has shown promise in understanding the role of extracellular vesicles in cell communication and healing, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- SCHEPENS EYE RESEARCH INSTITUTE — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YEUNG, VINCENT — SCHEPENS EYE RESEARCH INSTITUTE
- Study coordinator: YEUNG, VINCENT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.