Understanding how copper is transported and used in cells
Mechanisms of Copper Transport and Catalysis
This study is looking at how cells handle copper, an important nutrient, to make sure they have just the right amount—because too much can be harmful—and it’s especially focused on how harmful bacteria like E. coli manage copper to avoid being attacked by our immune system.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10828854 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which copper is transported and utilized in eukaryotic cells, focusing on its role as an essential enzymatic cofactor. The study examines how cells maintain copper at safe levels, as high concentrations can be toxic. It includes projects that explore the electron transfer pathways in specific enzymes and the export mechanisms of copper in pathogenic bacteria like E. coli. By using innovative labeling techniques, the research aims to track copper movement within cells and understand how pathogens manage copper levels to evade the immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by gram-negative bacteria or those with conditions related to copper metabolism.
Not a fit: Patients with conditions unrelated to copper transport or those not affected by gram-negative bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by copper-sensitive pathogens.
How similar studies have performed: Previous research has shown success in understanding metal transport mechanisms in cells, indicating that this approach has potential for significant findings.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Blackburn, Ninian J — Oregon Health & Science University
- Study coordinator: Blackburn, Ninian J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.