Understanding how copper affects metabolism and cell growth in Wilson's disease
Nuclear Receptor Dysfunction Reprograms Metabolism and Cellular Proliferation in Wilson's Disease
This study is looking at how too much copper affects the liver in people with Wilson's disease, using mice to find out more about the changes it causes, with the hope of discovering new ways to help treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11092299 on NIH RePORTER |
What this research studies
This research investigates the effects of copper accumulation in Wilson's disease, a genetic disorder that leads to excessive copper in the liver and brain. By studying mice that mimic this condition, the researchers aim to uncover how copper alters metabolic and cellular processes in the liver. They will analyze changes in gene expression and metabolic pathways to identify potential new therapeutic targets. The goal is to improve understanding of the disease and develop better treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Wilson's disease, particularly those experiencing liver-related symptoms.
Not a fit: Patients with Wilson's disease who are already well-managed on current therapies may not see additional benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively manage Wilson's disease with fewer side effects.
How similar studies have performed: Previous research has shown promising results in understanding metabolic disorders through similar approaches, indicating potential for success in this area.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Wooton-Kee, Clavia Ruth — Baylor College of Medicine
- Study coordinator: Wooton-Kee, Clavia Ruth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.