Understanding how copper affects liver function in Wilson disease
Copper Homeostasis and Liver Function
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11011353
This study is looking into Wilson disease, a condition where too much copper builds up in the body, to better understand how it affects the liver and to find new ways to treat it, focusing on how liver and gut health are connected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11011353 on ClinicalTrials.gov |
What this research studies
This research investigates Wilson disease, a serious metabolic disorder caused by genetic mutations that lead to copper accumulation in the body. By using advanced experimental models, the project aims to create a detailed understanding of how copper overload impacts liver function and to identify new treatment targets. The research will involve analyzing liver responses at the cellular level and exploring the role of immune cells in the disease process. Additionally, it will examine how the liver interacts with the gut in the context of Wilson disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Wilson disease or those who may be at risk due to genetic factors.
Not a fit: Patients with liver diseases unrelated to copper metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients with Wilson disease.
How similar studies have performed: Previous research has shown promise in understanding copper metabolism and its implications for liver health, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUTSENKO, SVETLANA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: LUTSENKO, SVETLANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.