Understanding how complex proteins function and communicate in the body
Official title: Defining Functional Dynamics of Multidomain Redox Enzymes
Funded at University of New Mexico Health Scis Ctr · NIH-11011675 · Data updated 2026-11-12
This study is looking at how certain important proteins in our bodies change shape and work with other molecules, especially focusing on enzymes that help with cell signaling and can affect various diseases, to help find new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $419,375 |
| NIH project number | 1R35GM156443-01 |
| Project ID | NIH-11011675 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to nitric oxide synthase dysfunction or other signaling pathway disorders.
✕Less likely to help
Patients with conditions unrelated to protein dynamics or those not affected by nitric oxide synthase may not benefit from this research.
What this research studies
This research investigates the dynamic behavior of multidomain proteins, which play crucial roles in various biological functions, including electron transfer. By employing advanced biophysical techniques, the project aims to uncover how these proteins change shape and interact with other molecules, which is essential for their function. The focus is on nitric oxide synthase enzymes, which are important for cell signaling and can influence various diseases. The study seeks to provide a deeper understanding of the regulatory mechanisms that control these proteins, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to dysfunctional protein signaling.
How similar studies have gone: Previous research has shown promise in understanding protein dynamics, but this approach aims to provide a more comprehensive view of multidomain proteins, making it a novel investigation.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Feng, Changjian — University of New Mexico Health Scis Ctr
- Study coordinator: Feng, Changjian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.