Understanding how complement proteins affect autoimmune uveitis
New mechanisms by which complementýregulates the pathogenesis of experimental autoimmune uveitis
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10834908
This study is looking at how certain proteins in the immune system affect a serious eye condition called autoimmune uveitis, which can cause blindness, and it's aimed at finding new ways to help prevent or lessen the impact of this disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10834908 on ClinicalTrials.gov |
What this research studies
This research investigates the role of complement proteins in the development of experimental autoimmune uveitis (EAU), a condition that can lead to blindness. By studying mice with specific deficiencies in complement components, the researchers aim to uncover how these proteins influence the behavior of immune cells in the retina. The approach includes using gene knockout models and novel reagents to explore potential therapeutic targets for treating autoimmune uveitis. The ultimate goal is to identify new strategies to prevent or reduce the severity of this eye disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune uveitis or those at risk of developing this condition.
Not a fit: Patients with non-autoimmune related eye conditions are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent blindness caused by autoimmune uveitis.
How similar studies have performed: Previous research has shown promise in targeting complement proteins for autoimmune conditions, suggesting potential for success in this area.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIN, FENG C — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: LIN, FENG C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.