Understanding how communication between peroxisomes and mitochondria affects aging
Official title: Role of peroxisome-mitochondrion communication in tissue aging
Funded at Iowa State University · NIH-11105953 · Data updated 2026-11-12
This study is looking at how two important parts of our cells, called peroxisomes and mitochondria, talk to each other and how that affects aging in our tissues, with the hope of finding ways to improve cell health as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $299,252 |
| NIH project number | 5R01AG075156-03 |
| Project ID | NIH-11105953 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may be experiencing age-related health issues.
✕Less likely to help
Patients under the age of 65 or those without age-related conditions may not benefit from this research.
What this research studies
This research investigates the communication between peroxisomes and mitochondria, two important cellular organelles, and how this interaction influences aging in tissues. By utilizing advanced techniques such as CRISPR genome editing, organelle proteomics, and metabolomics, the study aims to uncover the mechanisms behind age-related changes in these organelles. The goal is to determine how enhancing this communication can potentially mitigate the effects of aging on cellular function and health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving health and longevity in older adults.
How similar studies have gone: While the specific focus on peroxisome-mitochondrion communication is relatively novel, previous research has shown promising results in understanding organelle interactions and their impact on aging.
Where this research is happening
-
Iowa State University
Ames, United States Active
Researchers
- Principal investigator: Bai, Hua — Iowa State University
- Study coordinator: Bai, Hua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.