Understanding how common genetic variations affect health and evolution
Official title: Evolutionary and functional impact of common genomic structural variations
Funded at State University of New York at Buffalo · NIH-11011005 · Data updated 2026-11-12
This study is looking at how changes in our DNA, like missing or extra pieces, can affect our health and how our bodies work, especially in relation to diseases like diabetes, to help find better ways to understand and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $401,914 |
| NIH project number | 1R35GM156519-01 |
| Project ID | NIH-11011005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of metabolic disorders or immune-related diseases.
✕Less likely to help
Patients with rare genetic disorders unrelated to common genomic structural variations may not benefit from this research.
What this research studies
This research investigates the impact of genomic structural variations, such as deletions and duplications of DNA segments, on human health and evolution. By using advanced sequencing techniques and in vivo models, the team aims to uncover how these variations contribute to diseases like diabetes and affect immune functions. The study will explore the mechanisms behind these genetic changes and their implications for biological processes, potentially leading to new insights into disease risk and treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors influencing disease risk and better-targeted therapies for patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of genomic variations in health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Gokcumen, Omer — State University of New York at Buffalo
- Study coordinator: Gokcumen, Omer
Related research
Other NIH-funded projects on the same topics.
-
Improving population health by studying reproductive health and development.
This study is looking at how different factors, like the environment and genetics, affect the health of pregnant women and people of reproductive age, with the goal of improving pregnancy outcomes and the health of children as they grow up.
-
How noise and hearing loss affect the first step of hearing in the brain
This NIH grant studies how noise and conductive hearing loss change the intimate connections between auditory nerves and brain cells, which could influence how we hear in noisy environments.
-
Programmable hydrogels to protect transplanted human OPCs in demyelinating disease
Aims to improve survival and integration of transplanted human oligodendrocyte precursor cells by using specially designed hydrogels to reduce cell death during delivery in demyelinating diseases like multiple sclerosis.
-
How a mouth bacterium might fuel gum disease and heart risk
A small study will look at how a bacterium in the mouth that makes a reactive chemical (methylglyoxal) could drive gum inflammation and changes in the mouth’s bacteria, possibly linking to heart disease.
-
New dual-acting treatments against tough Klebsiella pneumoniae infections
A new funding opportunity aims to develop therapies that both fight and disarm the dangerous Klebsiella pneumoniae bacteria, especially strains that resist many drugs, to help patients with serious infections.
-
Muscle health and aging in postmenopausal women
This NIH grant supports a study in older, postmenopausal women to understand how insulin and blood sugar relate to muscle loss over time and whether this differs by race/ethnicity.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.