Understanding how common genetic variations affect health and evolution
Evolutionary and functional impact of common genomic structural variations
This study is looking at how changes in our DNA, like missing or extra pieces, can affect our health and how our bodies work, especially in relation to diseases like diabetes, to help find better ways to understand and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-11011005 on NIH RePORTER |
What this research studies
This research investigates the impact of genomic structural variations, such as deletions and duplications of DNA segments, on human health and evolution. By using advanced sequencing techniques and in vivo models, the team aims to uncover how these variations contribute to diseases like diabetes and affect immune functions. The study will explore the mechanisms behind these genetic changes and their implications for biological processes, potentially leading to new insights into disease risk and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of metabolic disorders or immune-related diseases.
Not a fit: Patients with rare genetic disorders unrelated to common genomic structural variations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors influencing disease risk and better-targeted therapies for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of genomic variations in health, suggesting that this approach could yield valuable insights.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Gokcumen, Omer — State University of New York at Buffalo
- Study coordinator: Gokcumen, Omer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.