Understanding how combinations of antibodies work together in the immune response
Mapping the effector response space of antibody combinations
['FUNDING_U01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10746824
This study is looking at how different pairs of antibodies work together to boost the immune system's ability to fight off diseases, and it’s for anyone interested in improving treatments that use antibodies to help the body eliminate sick cells.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10746824 on ClinicalTrials.gov |
What this research studies
This research investigates how different combinations of antibodies can produce unique immune responses that are not simply the sum of their individual effects. By using a computational model, the team aims to predict how these antibody combinations interact with immune cells to enhance their ability to target and eliminate diseased cells. The study will involve testing these combinations in laboratory settings to observe their effectiveness in killing targeted cells. Ultimately, this research seeks to improve the design of antibody therapies for various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that could benefit from antibody therapies, such as certain cancers or autoimmune diseases.
Not a fit: Patients who do not have conditions treatable by antibody therapies may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective antibody therapies that better harness the immune system to fight diseases.
How similar studies have performed: Previous research has shown promising results in understanding antibody interactions, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MEYER, AARON SAMUEL — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: MEYER, AARON SAMUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.