Understanding how colorectal cancer develops resistance to targeted therapies
Official title: Targeting Chromosomal Instability in the Evolution of Resistance to Matched Therapies Against Colorectal Cancer to Extend Treatment Response
Funded at Sloan-Kettering Inst Can Research · NIH-11111920 · Data updated 2026-11-12
This study is looking at how colorectal cancer can become resistant to certain treatments by examining changes in the cancer's genes, with the goal of finding new ways to make treatments work better for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $205,700 |
| NIH project number | 1R21CA292178-01A1 |
| Project ID | NIH-11111920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with metastatic colorectal cancer who are undergoing targeted therapy.
✕Less likely to help
Patients with early-stage colorectal cancer or those not receiving targeted therapies may not benefit from this research.
What this research studies
This research investigates the mechanisms behind how colorectal cancer (CRC) becomes resistant to targeted therapies, particularly focusing on genetic changes that occur in tumors. By analyzing chromosomal instability and gene amplifications, the study aims to identify vulnerabilities in cancer cells that could be targeted to improve treatment outcomes. Patients will be monitored for specific genetic markers that may indicate how their cancer is responding to therapy, potentially leading to more personalized treatment approaches.
Why it matters
Potential benefit: If successful, this research could lead to longer-lasting responses to targeted therapies for colorectal cancer patients.
How similar studies have gone: Previous research has shown that targeting genetic vulnerabilities in cancer cells can lead to improved treatment outcomes, suggesting that this approach may be promising.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Yaeger, Rona — Sloan-Kettering Inst Can Research
- Study coordinator: Yaeger, Rona
Related research
Other NIH-funded projects on the same topics.
-
Improving colorectal cancer screening and follow-up care.
This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.
-
Colorectal cancer prognosis through a broad, collaborative study
A large, multi-center study follows people newly diagnosed with colorectal cancer to find biomarkers and patterns that predict outcomes and guide future care.
-
Ceramides and how they affect metabolism and colorectal cancer in adults
A study in adults with obesity-related health issues will explore how a fat-related molecule called ceramide influences metabolic problems and colorectal cancer risk.
-
Automated point-of-care DNA methylation test for colorectal cancer in LMICs
A fast, affordable blood test using DNA markers to help identify people at higher risk of colorectal cancer in low- and middle-income countries.
-
Rewiring Colorectal Cancer to Harness Therapeutic Hyperactivation
A Yale team is exploring brain-storming new ways to treat colorectal cancer by safely boosting certain cancer signaling pathways to kill cancer cells and by reshaping cancer cell states to improve responses to existing therapies.
-
Comparative modeling to guide colorectal cancer screening and care
A researcher team will use computer models to study how access to care, risk, and new screening options affect colorectal cancer outcomes and costs for adults in the US.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.