Understanding how colon cancer spreads to the peritoneum
Defining the role of seed and soil in peritoneal metastasis evolution
['FUNDING_R01'] · HARVARD MEDICAL SCHOOL · NIH-11074604
This study is looking at how colon cancer spreads to the abdominal lining and what genetic changes happen during this process, with the goal of finding better ways to treat patients who experience this serious complication.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11074604 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic characteristics and evolutionary history of colon cancer metastasis to the peritoneum, which is a common and serious complication. By analyzing a large group of patients with peritoneal metastasis, the study aims to uncover how cancer cells reach the peritoneal cavity and how these pathways affect the genetic diversity of the metastases. The research will utilize advanced genomic analysis to link these genetic features to patient outcomes, potentially leading to improved treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colon cancer who have developed peritoneal metastasis.
Not a fit: Patients with colon cancer who do not have peritoneal metastasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with peritoneal metastasis from colon cancer.
How similar studies have performed: Previous research has shown promising results in understanding cancer metastasis through genetic analysis, indicating that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAXEROVA, KAMILA — HARVARD MEDICAL SCHOOL
- Study coordinator: NAXEROVA, KAMILA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell, cancer in the colon