Understanding how collagen differences affect breast cancer in African American women
Collagen Sequence Variants in Racial Disparities of Breast Cancer
This study is looking at how different types of collagen might affect breast cancer, especially in African American women, to help find better ways to predict and prevent aggressive forms of the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10881750 on NIH RePORTER |
What this research studies
This research investigates the role of collagen sequence variants in breast cancer, particularly focusing on African American women who experience higher mortality rates despite lower incidence. The study aims to uncover how collagen processing and structure contribute to aggressive forms of breast cancer, such as triple negative breast cancer (TNBC). By examining the ancestry-dependent mechanisms that influence collagen re-alignment, the research seeks to identify potential predictive markers for breast cancer progression and metastasis. This could lead to improved prevention strategies tailored specifically for African American women.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American women diagnosed with breast cancer, particularly those with triple negative breast cancer.
Not a fit: Patients who do not identify as African American or those without a breast cancer diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and prevention of breast cancer metastasis in African American women.
How similar studies have performed: Other research has shown promising results in understanding the role of collagen in cancer progression, but this specific focus on racial disparities is relatively novel.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Angel, Peggi M — Medical University of South Carolina
- Study coordinator: Angel, Peggi M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.