Understanding how cold storage damages the corneal endothelium
Official title: Molecular mechanisms of cold storage-induced damage to the corneal endothelium
Funded at Trustees of Indiana University · NIH-10741168 · Data updated 2026-11-12
This study is looking at how storing corneas in cold temperatures can harm the cells that keep them clear, with the goal of finding ways to protect these cells and improve results for people getting corneal transplants.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $432,191 |
| NIH project number | 1R21EY034650-01A1 |
| Project ID | NIH-10741168 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are undergoing or are candidates for corneal transplantation due to endothelial cell loss.
✕Less likely to help
Patients with corneal conditions unrelated to endothelial cell loss or those who do not require transplantation may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind the damage caused to the corneal endothelium during cold storage, which is crucial for maintaining corneal transparency. The study focuses on how prolonged cold storage affects the endothelial cells, particularly looking at changes in cell structure and function. By examining these processes, the research aims to identify potential interventions that could prevent cell loss during corneal transplantation. This could ultimately improve outcomes for patients undergoing this procedure.
Why it matters
Potential benefit: If successful, this research could lead to improved preservation techniques for corneal tissues, enhancing the success rates of corneal transplants.
How similar studies have gone: While the specific molecular mechanisms of cold storage-induced damage are not fully understood, similar research has shown promise in improving preservation techniques for other types of tissues.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Srinivas, Sangly P — Trustees of Indiana University
- Study coordinator: Srinivas, Sangly P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.