Understanding how cold sensations can cause pain
Molecular and cellular mechanisms of cold allodynia
This study is looking into why some people feel pain from cold temperatures and how certain nerve cells and molecules in the body are involved, with the hope of finding new ways to help relieve that pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11168262 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind cold allodynia, a condition where cold temperatures cause pain. It focuses on how specialized nerve cells in the body detect cold and how these signals are processed in the spinal cord. The study examines the role of a specific receptor, TRPM8, and a related molecule, artemin, in mediating both pleasant and painful cold sensations. By exploring these pathways, the research aims to uncover potential targets for new pain relief treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing cold allodynia or heightened sensitivity to cold due to injury or chronic pain conditions.
Not a fit: Patients who do not experience cold sensitivity or pain related to cold temperatures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for patients suffering from pain triggered by cold temperatures.
How similar studies have performed: Previous research has shown promising results in understanding pain mechanisms related to temperature, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Mckemy, David D — University of Southern California
- Study coordinator: Mckemy, David D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.