Understanding how cold pain works in the body
Official title: Molecular and Computational Dissection of Cold Nociception
Funded at Georgia State University · NIH-11384531 · Data updated 2026-11-12
This NIH grant studies the basic biology of how our nerves sense cold and how that links to pain, to help people who experience cold-induced pain someday.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 15, 2019 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $613,692 |
| NIH project number | 5R01NS115209-08 |
| Project ID | NIH-11384531 on NIH RePORTER |
Who could benefit from this research
✓Could help
This project is basic science, not a patient trial, so no specific patient group is recruited for this grant.
✕Less likely to help
No immediate patient participation; the study is preclinical in nature.
What this research studies
Researchers at Georgia State University will explore the cellular and molecular processes behind cold nociception, including how thermoTRP channels detect cold and interact with other signaling pathways. The work combines experiments on nerves and related tissues with computational analyses to map how cold temperatures trigger pain signals. Findings could clarify why some people develop neuropathic pain with cold exposure and point toward new ways to manage it. The project aims to translate basic discoveries into insights that may inform future therapies for pain relief.
Why it matters
Potential benefit: If successful, the research could lead to better understanding of cold-related pain and potentially new approaches to treat it.
How similar studies have gone: Previous work has shown that thermoTRP channels are involved in cold sensing, with growing evidence linking them to pain states.
Where this research is happening
-
Georgia State University
Atlanta, United States Active
Researchers
- Principal investigator: Cymbalyuk, Gennady S — Georgia State University
- Study coordinator: Cymbalyuk, Gennady S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.