Understanding how cohesin proteins work in vertebrate cells
Official title: Mechanisms of cohesin regulation in vertebrates
Funded at Oklahoma Medical Research Foundation · NIH-11059212 · Data updated 2026-11-12
This study looks at how special proteins called cohesins help keep the nucleus of our cells organized and working properly, which is important for things like cell division and repairing DNA, and it aims to learn more about how these proteins affect our health and development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | April 3, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $426,250 |
| NIH project number | 5R35GM149343-03 |
| Project ID | NIH-11059212 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or conditions that involve DNA repair deficiencies.
✕Less likely to help
Patients with conditions unrelated to DNA repair or chromosome segregation may not benefit from this research.
What this research studies
This research investigates the role of cohesin proteins in vertebrate cells, focusing on how they help maintain the structure and function of the nucleus. It explores how cohesin tethers sister chromatids during cell division and facilitates chromosome organization, which is crucial for accurate DNA repair and gene expression. By examining various vertebrate systems, including genome-modified cultured cells, the research aims to uncover the molecular mechanisms that regulate cohesin and its impact on cellular processes. This could lead to a better understanding of developmental biology and disease mechanisms.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic stability and inform new treatments for diseases related to DNA damage and repair.
How similar studies have gone: Previous research has shown promising results in understanding cohesin's role in other organisms, indicating potential for success in vertebrates as well.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Rankin, Susannah — Oklahoma Medical Research Foundation
- Study coordinator: Rankin, Susannah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.