Understanding how cognitive aging differs in adults with and without dementia

Defining rates of cognitive aging in adults with and without dementia using the CODA cohort

NIH-funded research Brown University · NIH-10947431

This study is looking at how our thinking skills change as we get older, especially comparing healthy adults to those with Alzheimer's or similar conditions, to help improve care for people with dementia.

Quick facts

Grant typeR03 grant
Study typeNIH-funded research
Funding institutionBrown University NIH-funded
Lab location1 site (Providence, United States)
Project IDNIH-10947431 on NIH RePORTER

What this research studies

This research aims to measure the normal rate of cognitive aging in adults who do not have neurocognitive disorders and compare it to the accelerated cognitive aging seen in individuals with Alzheimer's disease or related dementias. By analyzing data from the Children of the Depression cohort, the study will estimate cognitive performance and identify how quickly cognitive abilities decline with age. The research will also link this data with Medicare records to track dementia diagnoses over time, providing a clearer picture of cognitive aging patterns. This information could help in developing better care strategies for those affected by dementia.

Who could benefit from this research

Good fit: Ideal candidates for this research include adults aged 21 and older, both with and without a diagnosis of Alzheimer's disease or related dementias.

Not a fit: Patients who are younger than 21 or do not have any cognitive aging concerns may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide valuable insights into cognitive aging, potentially leading to improved diagnosis and treatment strategies for dementia.

How similar studies have performed: Previous research has successfully identified cognitive aging patterns, but this study aims to establish a normative reference that is currently lacking.

Where this research is happening

Providence, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementia
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.