Understanding how cognition and personality change in aging and Alzheimer's disease.
Official title: Within-person dynamics of cognition and personality in healthy aging and Alzheimer's disease.
Funded at Washington University · NIH-11023137 · Data updated 2026-11-12
This study is looking at how thinking skills and personality change as people get older, especially for those with Alzheimer's, to help find better ways to track these changes and improve care for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 15, 2021 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $95,482 |
| NIH project number | 5K01AG071847-05 |
| Project ID | NIH-11023137 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults aged 21 and older, particularly those with mild cognitive impairment or at risk for Alzheimer's disease.
✕Less likely to help
Patients with severe cognitive impairment or those not at risk for Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the fluctuations in cognitive function and personality traits in individuals as they age, particularly those with Alzheimer's disease. By using advanced statistical models, the study aims to capture daily variations in cognitive performance, which may reflect underlying biological and psychological processes. Participants will undergo assessments over a three-week period to identify patterns that could predict cognitive decline. The goal is to improve the measurement of cognitive function in clinical trials, potentially leading to better outcomes for patients.
Why it matters
Potential benefit: If successful, this research could lead to more accurate assessments of cognitive decline, improving treatment strategies for Alzheimer's disease.
How similar studies have gone: Other research has shown promise in using intensive longitudinal methods to understand cognitive variability, suggesting this approach could be effective.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Aschenbrenner, Andrew — Washington University
- Study coordinator: Aschenbrenner, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.