Understanding how cofilin signaling affects recovery after hemorrhagic stroke
Official title: Cofilin Signaling in Hemorrhagic Stroke
Funded at University of Toledo Health Sci Campus · NIH-10814140 · Data updated 2026-11-12
This study is looking at how a protein called cofilin affects brain recovery after a serious type of stroke, and it aims to find ways to help the brain heal better by using special treatments that target this protein, which could benefit people who have had a hemorrhagic stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | June 15, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $387,330 |
| NIH project number | 5R01NS112642-05 |
| Project ID | NIH-10814140 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have suffered a hemorrhagic stroke and are experiencing cognitive impairments or disabilities as a result.
✕Less likely to help
Patients who have not experienced a hemorrhagic stroke or those with other types of strokes may not benefit from this research.
What this research studies
This research investigates the role of cofilin, an actin-binding protein, in the aftermath of hemorrhagic stroke, which is a severe type of stroke that can lead to significant disabilities and cognitive impairments. The study focuses on how microglial cells, which respond to brain injuries, are activated and how this activation can contribute to further brain damage. By using animal models, the researchers aim to explore the effects of targeting cofilin with specific inhibitors to reduce brain damage and improve recovery outcomes. The findings could lead to new treatment strategies for patients suffering from intracerebral hemorrhage.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve recovery and reduce disabilities in patients who have experienced a hemorrhagic stroke.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in stroke recovery, indicating potential for success in this approach.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Shah, Zahoor Ahmad — University of Toledo Health Sci Campus
- Study coordinator: Shah, Zahoor Ahmad
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.