Understanding how Coenzyme A levels control the body's energy use
Changes in Coenzyme A Levels are a Key Mechanism Regulating Metabolic Pathways
This work explores how a vital molecule called Coenzyme A (CoA) helps manage your body's energy and metabolism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project ID | NIH-11087536 on NIH RePORTER |
What this research studies
Our bodies rely on Coenzyme A (CoA) to carry important building blocks for hundreds of metabolic reactions, which are processes that create energy and keep us healthy. This molecule is found in different parts of our cells, like the mitochondria, and its levels are carefully balanced in our tissues. When CoA levels are too high or too low, it can disrupt how our bodies use energy and affect organ function. This project aims to uncover the specific ways CoA levels are controlled, including how it's broken down, to better understand its role in health and disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies building on this knowledge could benefit individuals with metabolic disorders or conditions affecting energy expenditure.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of metabolic diseases and potentially new ways to manage conditions related to energy use and organ function.
How similar studies have performed: While the broad role of CoA in metabolism is known, the specific mechanisms of its regulation, particularly its degradation, are not well-understood, making this a novel area of focus.
Where this research is happening
Morgantown, United States
- West Virginia University — Morgantown, United States (Active)
Researchers
- Principal investigator: Leonardi, Roberta — West Virginia University
- Study coordinator: Leonardi, Roberta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.