Understanding how cocaine affects immune recovery in HIV-infected individuals
Investigate B cell perturbations and immune reconstitution failure in response to antiretroviral therapy in HIV-infected cocaine users
This study is looking at how using cocaine might affect the immune system of people with HIV who are on treatment, to help find better ways for them to recover their health.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10677040 on NIH RePORTER |
What this research studies
This research investigates the effects of cocaine use on the immune system of individuals living with HIV who are undergoing antiretroviral therapy (ART). It focuses on how cocaine may lead to the production of harmful antibodies that prevent the recovery of CD4+ T cells, which are crucial for a healthy immune response. By examining the relationship between cocaine use and immune function, the study aims to identify mechanisms that contribute to immune reconstitution failure in these patients. The ultimate goal is to find ways to enhance immune recovery and improve health outcomes for HIV-infected cocaine users.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-infected individuals who are on antiretroviral therapy and have a history of cocaine use.
Not a fit: Patients who are HIV-negative or those who do not use cocaine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune recovery in HIV-infected individuals who use cocaine, potentially reducing morbidity and mortality.
How similar studies have performed: While the specific approach of this research is novel, previous studies have indicated that substance use can negatively impact immune recovery in HIV-infected individuals.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Jiang, Wei — Medical University of South Carolina
- Study coordinator: Jiang, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.