Understanding how cocaine affects brain signaling related to addiction
Elucidating the Mechanisms and Relevance of Cocaine-Induced Plasticity of Inhibitory G Protein Signaling in the Prelimbic Cortex
This study is looking at how cocaine affects certain brain cells related to addiction in mice, with the hope of finding new ways to help people recover from cocaine use.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11066729 on NIH RePORTER |
What this research studies
This research investigates how cocaine alters the signaling pathways in specific brain cells that are involved in addiction. By studying the effects of cocaine on inhibitory G protein signaling in the prelimbic cortex of mice, the researchers aim to uncover the cellular and neurochemical changes that occur with repeated drug exposure. The approach involves genetic manipulation and behavioral assessments to understand how these changes contribute to addiction. The ultimate goal is to explore potential therapeutic strategies that could restore normal signaling in the brain affected by cocaine use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with cocaine addiction or those at risk of developing such an addiction.
Not a fit: Patients who do not use cocaine or have no history of substance abuse may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cocaine addiction by restoring normal brain signaling pathways.
How similar studies have performed: Previous research has shown promising results in understanding the neurobiological mechanisms of addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Welter, Alex Larsen — University of Minnesota
- Study coordinator: Welter, Alex Larsen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.