Understanding how CMYA5 affects heart cell structure and function
Official title: CMYA5 regulation of cardiac dyad structure and function
Funded at Boston Children's Hospital · NIH-10992161 · Data updated 2026-11-12
This study is looking at a protein called CMYA5 to see how it helps heart cells work properly, especially in forming important structures that help the heart contract and pump blood; understanding this could lead to new ways to treat heart problems like arrhythmias and heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $541,964 |
| NIH project number | 5R01HL163937-03 |
| Project ID | NIH-10992161 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart diseases, particularly those experiencing arrhythmias or heart failure.
✕Less likely to help
Patients with non-cardiac conditions or those whose heart function is not affected by dyad structure may not benefit from this research.
What this research studies
This research investigates the role of a protein called CMYA5 in the structure and function of heart cells, specifically focusing on how it helps form critical structures known as dyads. Dyads are essential for the heart's ability to contract properly by facilitating the release of calcium ions, which are crucial for heart muscle contractions. The study aims to uncover the molecular mechanisms behind dyad formation and how disruptions in this process can lead to heart diseases, including arrhythmias and heart failure. By using mouse models and examining human heart tissues, the research seeks to provide insights into potential therapeutic targets for improving heart function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart diseases by restoring normal heart cell function and preventing arrhythmias.
How similar studies have gone: Other research has shown promising results in understanding cardiac dyad structures, but the specific role of CMYA5 in this context is relatively novel.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Pu, William Tswenching — Boston Children's Hospital
- Study coordinator: Pu, William Tswenching
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.