Understanding how clusterin affects fluid drainage in the eye
Role of Clusterin in Aqueous Humor Outflow Physiology
This study is looking at how a protein called clusterin helps drain fluid from the eye, which is important for keeping eye pressure normal, and it could lead to new ways to help people with glaucoma manage their condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10683150 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called clusterin in the drainage of fluid from the eye, which is crucial for maintaining normal eye pressure. Elevated eye pressure is a significant risk factor for primary open angle glaucoma (POAG), a leading cause of blindness. The study aims to explore how clusterin influences the structure and function of tissues involved in fluid outflow, potentially leading to new treatments for lowering eye pressure. By examining the molecular mechanisms at play, the research seeks to provide insights that could improve patient outcomes in glaucoma management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with primary open angle glaucoma.
Not a fit: Patients with other types of glaucoma or those without elevated intraocular pressure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively lower eye pressure and prevent vision loss in glaucoma patients.
How similar studies have performed: Previous research has shown promising results in understanding the molecular mechanisms of eye pressure regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Pattabiraman, Padmanabhan Paranji — Indiana University Indianapolis
- Study coordinator: Pattabiraman, Padmanabhan Paranji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.