Understanding how Clostridioides difficile bacteria build their protective outer layer
Cell Envelope Biogenesis in Clostridioides difficile
This study is looking at how the protective layer of the Clostridioides difficile bacteria works, with the goal of finding new ways to create antibiotics that can help people with gut infections while keeping their good bacteria safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11098528 on NIH RePORTER |
What this research studies
This research investigates the unique features of the cell envelope of Clostridioides difficile, a bacterium responsible for severe gut infections. By exploring the genetics and biochemistry involved in how this bacterium constructs its protective layer, the research aims to identify new targets for antibiotics that can effectively treat infections without harming beneficial gut bacteria. The approach includes using advanced techniques such as microscopy and genetic analysis to uncover the roles of specific enzymes in cell wall formation. This could lead to the development of more effective treatments for patients suffering from C. difficile infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from recurrent or severe Clostridioides difficile infections.
Not a fit: Patients with infections caused by other bacteria or those who do not have C. difficile infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that specifically target C. difficile, improving treatment outcomes for patients with these infections.
How similar studies have performed: Other research has shown promise in targeting bacterial cell envelopes for antibiotic development, suggesting that this approach could be effective.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Ellermeier, Craig D — University of Iowa
- Study coordinator: Ellermeier, Craig D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.