Understanding how cisplatin affects kidney function and finding ways to prevent damage
New mouse model of cisplatin-induced AKI and development of prevention therapy
This study is looking at how the cancer drug cisplatin can harm the kidneys, especially causing acute kidney injury, and aims to find ways to protect kidney health for cancer patients who need this treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10904742 on NIH RePORTER |
What this research studies
This research investigates the harmful effects of cisplatin, a common cancer treatment, on kidney health, specifically focusing on acute kidney injury (AKI) that affects many cancer patients. The study uses a mouse model to explore the molecular mechanisms behind cisplatin-induced kidney damage, particularly looking at oxidative stress and mitochondrial dysfunction. By analyzing kidney tissue samples from both mice and cancer patients, the researchers aim to identify potential therapeutic targets to prevent or mitigate kidney injury caused by cisplatin. The ultimate goal is to develop effective prevention strategies for patients undergoing cisplatin treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are being treated with cisplatin and are at risk for acute kidney injury.
Not a fit: Patients who are not receiving cisplatin or those with pre-existing severe kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect kidney function in cancer patients receiving cisplatin.
How similar studies have performed: Previous research has shown promising results in understanding kidney damage mechanisms, but this specific approach using a mouse model for cisplatin-induced AKI is relatively novel.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Zhao, Jianjun — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Zhao, Jianjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.