Understanding how circulating glioma cells contribute to brain tumor growth
Dissecting the biology and consequence of circulating glioma cells
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10830434
This study is looking at how certain cells in the blood might help glioblastoma, a tough brain tumor, come back after treatment, and it aims to find new ways to help patients live longer and healthier lives.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10830434 on ClinicalTrials.gov |
What this research studies
This research investigates the role of circulating glioma cells (CGCs) in the recurrence of glioblastoma, a highly aggressive brain tumor. By analyzing human specimens and using mouse models, the study aims to uncover how these cells, which exhibit stem cell-like properties, can migrate to tumor sites and promote tumor regrowth. The approach includes isolating and characterizing these cells to better understand their behavior and resistance to conventional treatments. The ultimate goal is to identify new therapeutic strategies that could improve survival rates for patients with glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma multiforme, particularly those experiencing tumor recurrence.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that effectively target glioblastoma recurrence, potentially improving survival rates for patients.
How similar studies have performed: Previous research has indicated that targeting cancer stem cells can be effective in treating various malignancies, suggesting that this approach may hold promise for glioblastoma as well.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DORSEY, JAY FITZGERALD — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: DORSEY, JAY FITZGERALD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers