Understanding how circadian rhythms affect cellular signaling pathways
MAPK signaling: gates, oscillators and circadian timing
This study is looking at how a specific pathway in the brain helps control our body's daily rhythms, which are important for our overall health, and it's using special mice to see how changes in this pathway might affect our daily behaviors and well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10596087 on NIH RePORTER |
What this research studies
This research investigates the role of the MAPK signaling pathway in regulating circadian rhythms, which are essential for various physiological processes in the body. The study focuses on the suprachiasmatic nucleus (SCN) in the hypothalamus, which acts as the master clock for timing these rhythms. By using animal models, specifically knockout mice, the researchers aim to uncover how the daily fluctuations in MAPK activity influence physiological states and behaviors. This could lead to insights into how disruptions in circadian rhythms may affect health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals experiencing circadian rhythm disorders or related health issues.
Not a fit: Patients with stable circadian rhythms and no related health concerns may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to circadian rhythm disruptions, such as sleep disorders and metabolic diseases.
How similar studies have performed: Previous research has shown that understanding circadian rhythms can lead to significant advancements in treating related health issues, indicating that this approach has potential for success.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Obrietan, Karl H — Ohio State University
- Study coordinator: Obrietan, Karl H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.