Understanding how cilia function in respiratory diseases
Quantitative analysis of mucociliary clearance in airway ciliopathies
This study is looking at how problems with tiny hair-like structures in the lungs, called cilia, can make it harder for the body to clear mucus and debris, which is important for people with lung conditions like asthma and cystic fibrosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10809567 on NIH RePORTER |
What this research studies
This research investigates how defects in cilia, which are tiny hair-like structures in the lungs, affect the body's ability to clear mucus and debris from the airways. By examining lung tissues that maintain their natural structure, the study aims to uncover the relationship between genetic factors, cilia movement, and respiratory health. The goal is to better understand how specific genetic mutations lead to various lung diseases, including asthma and cystic fibrosis, and how these conditions can be managed more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with primary ciliary dyskinesia, asthma, chronic bronchitis, or cystic fibrosis.
Not a fit: Patients with respiratory conditions not related to ciliary dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients with respiratory diseases linked to ciliary dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding ciliary function and its impact on respiratory health, indicating that this approach has potential for significant insights.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Ryan, Amy Leanne — University of Iowa
- Study coordinator: Ryan, Amy Leanne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.