Understanding how cilia affect kidney disease progression
Ciliary Disassembly, a modifier of Autosomal Dominant Polycystic Kidney Disease
This study is looking at how tiny hair-like structures on cells, called cilia, affect the growth of cysts in people with Autosomal Dominant Polycystic Kidney Disease (ADPKD), and it hopes to find new ways to slow down the disease by understanding how these cilia work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10765648 on NIH RePORTER |
What this research studies
This research investigates the role of cilia, small hair-like structures on cells, in the progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD). It aims to understand how mutations in specific genes lead to increased cell growth and cyst formation in the kidneys. By studying the processes of cilia assembly and disassembly, the research seeks to identify potential therapeutic approaches that could slow down disease progression. The study utilizes genetic and pharmacologic methods in mouse models to explore these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease.
Not a fit: Patients without a diagnosis of Autosomal Dominant Polycystic Kidney Disease or those with other unrelated kidney disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of kidney disease in patients with ADPKD.
How similar studies have performed: Previous research has shown promising results in understanding the role of cilia in kidney disease, indicating that this approach has potential for success.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Tsiokas, Leonidas — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Tsiokas, Leonidas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.