Understanding how cilia affect heart development and disease
Cilia in Heart Development and Disease
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11042738
This study is looking into how tiny hair-like structures called cilia might cause heart problems in babies born with congenital heart disease, and it aims to find better ways to help those affected.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11042738 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cilia in congenital heart disease (CHD), the most common birth defect affecting infants. It aims to uncover how dysfunction in cilia contributes to heart development issues by utilizing advanced techniques such as single-cell RNA sequencing and live-cell imaging. The research team, which includes experts in various fields, will explore the genetic factors involved in CHD and how they relate to clinical outcomes. By understanding these mechanisms, the study hopes to improve treatment strategies for individuals affected by CHD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital heart disease or those with a family history of heart defects.
Not a fit: Patients without congenital heart disease or related genetic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for congenital heart disease, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding genetic contributions to congenital heart disease, indicating that this approach may yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRUECKNER, MARTINA — YALE UNIVERSITY
- Study coordinator: BRUECKNER, MARTINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Candidate Disease Gene