Understanding how cilia affect cell signaling
Genetic Dissection of Signaling and Cilia
['FUNDING_OTHER'] · EMORY UNIVERSITY · NIH-11215095
This study is looking at tiny structures in our cells called cilia and how they help control important signals in the body, especially one called Sonic hedgehog, by focusing on a protein named ARL13B; it's for anyone interested in understanding how problems with these tiny structures can lead to certain health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11215095 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cilia, small cellular structures, in regulating important signaling pathways, particularly focusing on the Sonic hedgehog (Shh) signaling pathway. By studying a specific protein called ARL13B, which is crucial for cilia function, the researchers aim to uncover how genetic mutations can disrupt both cilia formation and signaling processes. Using genetically modified mice, they will explore the interactions between ARL13B and other proteins involved in these pathways, providing insights into how these mechanisms operate in living organisms. This work could lead to a better understanding of various diseases linked to cilia dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders related to cilia dysfunction or signaling pathway abnormalities.
Not a fit: Patients with conditions unrelated to cilia or the specific signaling pathways being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into diseases caused by cilia dysfunction, potentially informing new treatment strategies.
How similar studies have performed: Previous research has shown promising results in understanding cilia's role in signaling, suggesting that this approach could yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CASPARY, TAMARA J. — EMORY UNIVERSITY
- Study coordinator: CASPARY, TAMARA J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.