Understanding how cilia affect cell signaling
Genetic Dissection of Signaling and Cilia
['FUNDING_OTHER'] · EMORY UNIVERSITY · NIH-11004041
This study is looking at tiny structures in our cells called cilia and how they help control important signals in the body, especially one called Sonic hedgehog, by focusing on a protein named ARL13B; it's for anyone interested in understanding how genetic changes might affect cilia and lead to certain health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11004041 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cilia, small cellular structures, in regulating important signaling pathways, particularly focusing on the Sonic hedgehog (Shh) signaling pathway. By studying a specific protein called ARL13B, which is crucial for cilia function, the researchers aim to uncover how genetic mutations can disrupt both cilia formation and signaling processes. The approach involves creating mouse models with specific genetic alterations to observe the effects on cilia and signaling in real-time. This research could provide insights into the underlying mechanisms of various diseases linked to cilia dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders related to cilia or signaling pathways, particularly those affecting neural development.
Not a fit: Patients with conditions unrelated to cilia function or genetic signaling pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by cilia dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding cilia's role in signaling, indicating that this approach has potential for significant discoveries.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CASPARY, TAMARA J. — EMORY UNIVERSITY
- Study coordinator: CASPARY, TAMARA J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.