Understanding how cilia affect cell signaling
Official title: Genetic Dissection of Signaling and Cilia
Funded at Emory University · NIH-11004041 · Data updated 2026-11-12
This study is looking at tiny structures in our cells called cilia and how they help control important signals in the body, especially one called Sonic hedgehog, by focusing on a protein named ARL13B; it's for anyone interested in understanding how genetic changes might affect cilia and lead to certain health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $405,361 |
| NIH project number | 5R35GM148416-03 |
| Project ID | NIH-11004041 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders related to cilia or signaling pathways, particularly those affecting neural development.
✕Less likely to help
Patients with conditions unrelated to cilia function or genetic signaling pathways may not benefit from this research.
What this research studies
This research investigates the role of cilia, small cellular structures, in regulating important signaling pathways, particularly focusing on the Sonic hedgehog (Shh) signaling pathway. By studying a specific protein called ARL13B, which is crucial for cilia function, the researchers aim to uncover how genetic mutations can disrupt both cilia formation and signaling processes. The approach involves creating mouse models with specific genetic alterations to observe the effects on cilia and signaling in real-time. This research could provide insights into the underlying mechanisms of various diseases linked to cilia dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by cilia dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding cilia's role in signaling, indicating that this approach has potential for significant discoveries.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Caspary, Tamara J. — Emory University
- Study coordinator: Caspary, Tamara J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.