NIH-funded research R01 grant

Understanding how chronic pain affects emotions and thinking in dogs.

Official title: Innovative modeling of the biopsychosocial model in animals: Validation of outcomes for assessing emotional and cognitive domains affected by naturally-occurring chronic pain in dogs

Funded at North Carolina State University Raleigh · NIH-11050788 · Data updated 2026-11-12

This study looks at how chronic pain from osteoarthritis affects the feelings and thinking of pet dogs, and it aims to create new ways to measure these impacts so we can find better treatments for both dogs and people dealing with similar pain.

More Chronic Pain research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNorth Carolina State University Raleigh
NIH-funded
Lab location1 site (Raleigh, United States)
Project startSeptember 18, 2024
Project endAugust 31, 2027
Funding year2024
Award (this year)$3,320,159
NIH project number1R01AR085335-01
Project IDNIH-11050788 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are pet dogs diagnosed with chronic osteoarthritis.

Less likely to help

Patients who do not own dogs or whose dogs do not have chronic pain conditions may not benefit from this research.

What this research studies

This research investigates the emotional and cognitive impacts of chronic pain, specifically osteoarthritis, in pet dogs. By developing and validating new assessment tools, the study aims to better understand how pain affects dogs' behavior and mental functions. The findings could help improve treatment strategies for both dogs and humans suffering from similar conditions. The research utilizes a unique animal model to bridge the gap between human and animal pain experiences.

Why it matters

Potential benefit: If successful, this research could lead to improved pain management strategies for dogs, enhancing their quality of life.

How similar studies have gone: While research on chronic pain in animals is ongoing, this specific approach of integrating emotional and cognitive assessments in dogs is relatively novel.

Where this research is happening

  • North Carolina State University Raleigh
    Raleigh, United States
    Active

Researchers

  • Principal investigator: Gruen, Margaret Elizabeth — North Carolina State University Raleigh
  • Study coordinator: Gruen, Margaret Elizabeth

Related research

Other NIH-funded projects on the same topics.

  • Motor cortex tricks to ease chronic pain

    A study in rodents and people tests whether non-invasive brain stimulation of the motor cortex can reduce chronic pain and how best to target it.

    NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11621209

  • Human pain center study to map normal and migraine-trigeminal neurons

    A large NIH-funded project will map and study the human trigeminal neurons involved in migraines to understand what changes in these cells during headache conditions.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615140

  • Understanding human pain neurons to improve migraine care

    Researchers are studying human pain-sensing neurons to uncover what makes migraine start and persist, with the goal of better treatments for people who experience migraines.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615139

  • Whole Person Pain Algorithm to personalize chronic pain care

    A new, evidence-based model helps explain why chronic low back pain affects people differently and could guide personalized diagnosis and treatment.

    NIH research University of Florida · Gainesville, United States · NIH-11609318

  • Understanding how to use pharmacogenomic testing to guide chronic pain care

    This grant looks at how doctors who treat long‑term pain decide when and how to use genetic testing to tailor pain medicines for safer and more effective care.

    NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11602241

  • Mindfulness and Self-Hypnosis for Pain in Older Adults

    This grant tests non-drug ways like mindfulness and self-hypnosis to help people over 60 manage chronic pain.

    NIH research University of Washington · Seattle, United States · NIH-11599794

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.