Understanding how chronic lymphocytic leukemia changes into Richter's syndrome
Tracing the Evolution of Chronic Lymphocytic Leukemia to Richter's Syndrome: Defining Transformation
This study is looking at how chronic lymphocytic leukemia (CLL) changes into a more serious condition called Richter's syndrome (RS) to help doctors understand why this happens and find better ways to treat patients like you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10911251 on NIH RePORTER |
What this research studies
This research investigates the genetic changes that occur when chronic lymphocytic leukemia (CLL) transforms into Richter's syndrome (RS), a condition that complicates treatment and worsens patient outcomes. By analyzing patient samples, the study aims to identify the genetic and epigenetic factors that drive this transformation. The approach includes advanced genomic techniques to trace the evolution of CLL to RS, which could lead to better prognostic tools and targeted therapies for patients. The findings may help in understanding why some patients experience this transformation and how to prevent it.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with chronic lymphocytic leukemia, particularly those who may be at risk of or have developed Richter's syndrome.
Not a fit: Patients with other types of leukemia or those who do not have chronic lymphocytic leukemia will likely not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for patients with chronic lymphocytic leukemia who are at risk of developing Richter's syndrome.
How similar studies have performed: Other research has shown promise in understanding genetic transformations in cancers, suggesting that this approach may yield valuable insights into the transition from CLL to RS.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Parry, Erin M — Dana-Farber Cancer Inst
- Study coordinator: Parry, Erin M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.