Understanding how chronic inflammation affects blood vessel cells in pulmonary arterial hypertension
Generation of Endothelial Cell Memory in Inflammatory Vascular Disease
This study is looking at how long-lasting inflammation from a specific infection can affect blood vessels in the lungs and lead to a serious condition called pulmonary arterial hypertension (PAH), with the hope of finding new ways to treat it for patients like you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10888356 on NIH RePORTER |
What this research studies
This research investigates the role of chronic inflammation, particularly from Schistosoma mansoni infection, in the development of pulmonary arterial hypertension (PAH). It focuses on how endothelial cells, which line blood vessels, change in response to this inflammation and how these changes may lead to severe vascular lesions. By studying the memory of these cells and their signaling pathways, the research aims to identify new molecular targets for treating PAH. Patients may benefit from insights that could lead to novel therapies for this life-threatening condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly those with a history of chronic inflammation or Schistosoma mansoni infection.
Not a fit: Patients without pulmonary arterial hypertension or those whose condition is not related to chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pulmonary arterial hypertension, improving outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of chronic inflammation in vascular diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Dos Santos Oliveira, Suellen D'arc — University of Illinois at Chicago
- Study coordinator: Dos Santos Oliveira, Suellen D'arc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.