Understanding how chronic alcohol use leads to liver cancer
Official title: Mechanisms that promote hepatocellular carcinoma due to chronic ethanol exposure
Funded at Catholic University of America · NIH-10837104 · Data updated 2026-11-12
This study is looking at how drinking alcohol over a long time can lead to liver cancer, focusing on certain genetic changes that might help us find better ways to diagnose and treat this condition for people who are affected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Catholic University of America NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | May 5, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $224,039 |
| NIH project number | 5R21AA030353-02 |
| Project ID | NIH-10837104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of chronic alcohol consumption who are at risk for developing hepatocellular carcinoma.
✕Less likely to help
Patients who do not have a history of alcohol use or those with liver cancer caused by other factors may not benefit from this research.
What this research studies
This research investigates the biological mechanisms that contribute to the development of hepatocellular carcinoma (HCC) in individuals with a history of chronic alcohol consumption. The study focuses on specific genetic changes, particularly the amplification of chromosome 8q24, which is linked to increased levels of the c-Myc protein. By exploring how these changes influence cell behavior and the transition between different cell types, the research aims to identify unique pathways that could lead to targeted treatments for alcohol-related HCC. Patients may benefit from insights that could improve diagnosis and treatment strategies tailored to their specific condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and better outcomes for patients with liver cancer caused by alcohol use.
How similar studies have gone: While the specific mechanisms being studied may be novel, there is existing research indicating that understanding genetic factors in cancer can lead to significant advancements in treatment.
Where this research is happening
-
Catholic University of America
Washington, United States Active
Researchers
- Principal investigator: Tuma, Pamela L. — Catholic University of America
- Study coordinator: Tuma, Pamela L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.