Understanding how chromothripsis affects cancer development
Dissecting the role of the Fanconi anemia pathway in chromothripsis
This study is looking into how certain genetic changes happen in cancer, specifically focusing on a process called chromothripsis, and it aims to help patients understand more about how their cancer develops and find new ways to treat it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10996542 on NIH RePORTER |
What this research studies
This research investigates the phenomenon of chromothripsis, where chromosomes shatter and reassemble, leading to genetic abnormalities in cancer. The study focuses on the role of the Fanconi anemia pathway in this process, exploring how errors during cell division can create micronuclei that trap mis-segregated chromosomes. By examining the mechanisms behind these chromosomal rearrangements, the research aims to uncover new insights into cancer biology and potential therapeutic targets. Patients may benefit from a deeper understanding of how their cancer develops at a genetic level.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cancers that exhibit chromosomal abnormalities, particularly those with a history of genomic instability.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not involve chromothripsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating cancers associated with chromothripsis.
How similar studies have performed: Previous research has shown promising results in understanding chromosomal abnormalities in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Engel, Justin — Ut Southwestern Medical Center
- Study coordinator: Engel, Justin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.