Understanding how chromosomes separate during female egg development
Signaling Mechanisms that Control Chromosome Segregation during Female Meiosis
This study is looking at how certain proteins help ensure that chromosomes divide correctly when a woman's eggs are formed, which is really important for healthy reproduction, and it could help us understand some of the reasons behind infertility and birth defects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project ID | NIH-10893012 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control chromosome segregation during the formation of female gametes, which is crucial for successful reproduction. The study focuses on the role of specific proteins, known as Aurora kinases, that are essential for the proper division of chromosomes in oocytes. By using genetically modified mice, researchers aim to uncover how these proteins interact and function uniquely in female meiosis, which could help explain high rates of infertility and birth defects linked to errors in this process.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing infertility, miscarriages, or those with a history of birth defects.
Not a fit: Patients who are not female or those who do not have issues related to chromosome segregation or reproductive health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility and congenital abnormalities in women.
How similar studies have performed: Previous research has shown that understanding the roles of specific proteins in cell division can lead to significant advancements in reproductive health, indicating that this approach has potential for success.
Where this research is happening
Piscataway, United States
- Rutgers, the State Univ of N.j. — Piscataway, United States (Active)
Researchers
- Principal investigator: Schindler, Karen a — Rutgers, the State Univ of N.j.
- Study coordinator: Schindler, Karen a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.