Understanding how chromosomes separate correctly during cell division
Official title: Centromere behaviors that promote proper chromosome segregation in meiosis and mitosis
Funded at Oklahoma Medical Research Foundation · NIH-11001117 · Data updated 2026-11-12
This study is looking at how cells make sure their chromosomes are separated correctly during division, which is important for preventing issues like birth defects and infertility, and it's designed for anyone interested in understanding how our cells work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $383,625 |
| NIH project number | 5R35GM152165-02 |
| Project ID | NIH-11001117 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing infertility or those with a history of birth defects related to chromosomal issues.
✕Less likely to help
Patients with chromosomal abnormalities not related to aneuploidy or those without reproductive concerns may not benefit from this research.
What this research studies
This research investigates the mechanisms that ensure chromosomes are accurately pulled apart during cell division, specifically in meiosis and mitosis. It focuses on how microtubules attach to chromosomes at their kinetochores and the role of tension and connections between chromosomes in maintaining proper segregation. By studying these processes, the research aims to uncover the causes of chromosome imbalances, which can lead to conditions such as birth defects and infertility. The project includes multiple experiments to explore these mechanisms in detail.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility and birth defects caused by chromosomal abnormalities.
How similar studies have gone: Previous research has shown success in understanding chromosome segregation mechanisms, indicating that this approach has a foundation in established scientific inquiry.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Dawson, Dean S — Oklahoma Medical Research Foundation
- Study coordinator: Dawson, Dean S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.